席琳·迪翁重获嗓音，部分归功于一种药物的再利用
https://www.linkedin.com/posts/davidfajgenbaum_drugrepurposing-everycure-stiffpersonsyndrome-activity-7241876072336691202-SFon/
作者：大卫·法根鲍姆，医学博士、工商管理硕士、理学硕士
宾夕法尼亚大学医师科学家 | Every Cure 联合创始人兼总裁 | 畅销书《追寻我的治愈之路》作者
2025 TED 医师科学家
关于大卫·法根鲍姆
医学博士、工商管理硕士、理学硕士，是 Every Cure 的联合创始人兼总裁，也是宾夕法尼亚大学的医师科学家。他是宾夕法尼亚大学医学院有史以来最年轻的终身教职人员之一。他也是畅销书《追寻我的治愈：一位医生将希望化为行动的竞赛》（Chasing My Cure: A Doctor’s Race to Turn Hope Into Action）的作者，该书已被《阿甘正传》制片人温迪·芬纳曼改编成电影。
席琳·迪翁重获歌喉，部分要归功于一种重新利用的药物！
她被诊断出患有僵人综合征，这是一种罕见疾病，使她失去了行走、说话和唱歌的能力。她与病魔进行了一场鼓舞人心的斗争。
通过高强度的物理治疗和使用静脉注射免疫球蛋白（IVIg，一种最初于1952年开发的药物），她得以恢复部分健康。
这个使用IVIg治疗僵人综合征的有力案例，正是“万能疗法”（Every Cure）存在的意义所在——发掘更多类似的用途，确保每位患者都能从现有药物中受益。
人类进步（编辑）1年前
我建议谨慎使用“……恢复健康”和“……她取得了显著的康复”这两个短语。静脉注射免疫球蛋白（IVIg）并非SPS的治愈方法，如果给人造成它能治愈SPS的印象，那就太草率了。IVIg对她和其他SPS患者的作用是减轻症状、延缓病情进展并增强活动能力，而不是治愈。我理解帖子的用意，但作为一名SPS患者的照护者，我陪妻子接受IVIg输注近60次，我可以肯定地说，IVIg无疑是对抗SPS、提高生活质量的有效手段，但绝非万能药。
Kevin Welsh • 3rd+
David Fajgenbaum，医学博士、工商管理硕士、理学硕士：我最近加入了一家在医疗保健领域人工智能方面做出卓越贡献的公司。我非常希望能与您和您的团队交流，并分享更多信息。特别是关于我们如何创建患者的数字孪生模型——模拟每位患者独特的生理、神经和免疫特征的虚拟模型。这些数字孪生模型可以让您的团队在将治疗方案应用于患者之前，在虚拟环境中测试各种治疗方案。请联系 kevin@dv8.bz 或直接发送消息。谢谢！
Lauren McDermott • 3rd+
感谢您分享这些信息。静脉注射免疫球蛋白 (IVIg) 让我得以从僵人综合征 (SPS) 的折磨中恢复过来。虽然它不如以前那么有效，但仍然有助于减轻痉挛和疼痛。
Lauren McDermott
非常感谢您分享您的经历。我很高兴听到它对您有所帮助。希望它现在也能像以前一样有效。期待未来的治疗方法。
Tara Zier • 3rd+
正如 Lauren McDermott 所提到的，许多 SPS 患者都有类似的经历，即 IVIG 有助于减轻症状，但随着时间的推移，其疗效会逐渐减弱。我还想强调的是，即使 SPS 患者在短时间内能够保持高水平的竞技状态，也不意味着他们的病情已经好转。事件发生前后的“前后”都可能非常残酷。我对此深有体会。我们需要更好的SPS治疗方法，也许它正被束之高阁。正因如此，我非常感激您所做的一切，David Fajgenbaum，医学博士、工商管理硕士、理学硕士。谢谢您！！
Daniel Adongo博士 • 第三任及以上
主席
恭喜您！来自www.apostledanieladongo.org，他同时也是一位著作颇丰的作家，以及一位ICF认证的生活教练。我曾在我的著作《振动法则——西利塔·姆贝雷雷疗愈之水（系列三）》中提到过您从危及生命的疾病中幸存下来的鼓舞人心的故事。
Celine Dion got her voice back thanks in part to a repurposed drug
https://www.linkedin.com/posts/davidfajgenbaum_drugrepurposing-everycure-stiffpersonsyndrome-activity-7241876072336691202-SFon/
By David Fajgenbaum, MD, MBA, MSc
Physician-Scientist @ UPenn | Co-Founder & President @ Every Cure | Bestselling Author, Chasing My Cure
2025 TEDPhysician-Scientist 2025 TED
About David Fajgenbaum
MD, MBA, MSc, is co-Founder & President of Every Cure and a physician-scientist at the University of Pennsylvania, where he is one of the youngest faculty members ever to receive tenure at Penn Medicine. He is also the national bestselling author of Chasing My Cure: A Doctor’s Race to Turn Hope Into Action, which is being adapted into a film by Forrest Gump producer Wendy Finerman.
Celine Dion got her voice back thanks in part to a repurposed drug!
Diagnosed with stiff person syndrome, a rare disease that took away her ability to walk, talk, and sing, she has fought an inspiring battle.
Through intense physical therapy and the use of IVIg, a repurposed drug originally developed in 1952, she was able to regain some of her health.
This powerful example of using IVIg for stiff person syndrome is exactly why Every Cure exists—to uncover more uses like this and ensure that every patient can benefit from existing medicines.
Human Progress(edited) 1y
I would caution using the phrases, "...regain her health." AND "...she was able to make a remarkable recovery." IVIg is not a cure for SPS and would be reckless to give the impression it provided her with a cure. What IVIg enabled for her, and others suffering from SPS, is a lessening of symptoms and the potential slowing of progression and the strength to perform, not a cure. I appreciate the sentiment of the post but as a care giver of someone with SPS, who's taken his wife to IVIg infusions almost 60 times, IVIg is certainly a wonderful tool, in the arsenal to fight SPS and improve quality of life, but by no means a panacea.
Kevin Welsh • 3rd+
David Fajgenbaum, MD, MBA, MSc I've recently joined a company that is doing remarkable things in Artificial General Intelligence in healthcare. I'd love to connect and show you and your team more. Particularly around how we can create a digital twin of patients—virtual models that simulate each patient's unique physiological, neurological, and immunological characteristics. These digital twins would allow your team to test various treatment scenarios in a virtual environment before applying them to the patient. Reach out to kevin@dv8.bz or connect in direct message. Thank you!
Lauren McDermott • 3rd+
Thank you for sharing this information. IVIg has kept me alive with Stiff Person Syndrome. It’s not as effective as it used to be, but it still helps with reducing spasms and pain.
Lauren McDermott
thanks so much for sharing about your experience. I’m so glad to hear that it’s helped you. Wish it was as effective now as it was before. Hopeful for future treatments.
Tara Zier • 3rd+
As Lauren McDermott mentioned, many SPS patients have a similar experience where IVIG helps reduce symptoms but loses effectiveness over time. I also want to emphasize just because someone with SPS can perform at a high level for a brief period of time doesn’t mean they are better. The “before” and “after” the event can be brutal. I can speak to this from personal experience. We need a better treatment for SPS and maybe it is sitting on a shelf. That’s why I’m grateful for all of the work you are doing David Fajgenbaum, MD, MBA, MSc. Thank you!!
Dr. Daniel Adongo • 3rd+
President
Congratulations from here at: www.apostledanieladongo.org who is ALSO an AUTHOR of many books and an ICF Certified Life Coach. I actually mention your INSPIRING story of survival from a life-threatening disease in one of my books Entitled: "The Law of Vibration - On The Healing Waters of Silita Mberere (Series III).
荒谬 免疫球蛋白治愈 Celine Dion
风萧萧_Frank (2026-02-13 00:44:25) 评论 (0)
席琳·迪翁重获嗓音，部分归功于一种药物的再利用
https://www.linkedin.com/posts/davidfajgenbaum_drugrepurposing-everycure-stiffpersonsyndrome-activity-7241876072336691202-SFon/
作者：大卫·法根鲍姆，医学博士、工商管理硕士、理学硕士
宾夕法尼亚大学医师科学家 | Every Cure 联合创始人兼总裁 | 畅销书《追寻我的治愈之路》作者
2025 TED 医师科学家
关于大卫·法根鲍姆
医学博士、工商管理硕士、理学硕士，是 Every Cure 的联合创始人兼总裁，也是宾夕法尼亚大学的医师科学家。他是宾夕法尼亚大学医学院有史以来最年轻的终身教职人员之一。他也是畅销书《追寻我的治愈：一位医生将希望化为行动的竞赛》（Chasing My Cure: A Doctor’s Race to Turn Hope Into Action）的作者，该书已被《阿甘正传》制片人温迪·芬纳曼改编成电影。
席琳·迪翁重获歌喉，部分要归功于一种重新利用的药物！
她被诊断出患有僵人综合征，这是一种罕见疾病，使她失去了行走、说话和唱歌的能力。她与病魔进行了一场鼓舞人心的斗争。
通过高强度的物理治疗和使用静脉注射免疫球蛋白（IVIg，一种最初于1952年开发的药物），她得以恢复部分健康。
这个使用IVIg治疗僵人综合征的有力案例，正是“万能疗法”（Every Cure）存在的意义所在——发掘更多类似的用途，确保每位患者都能从现有药物中受益。
人类进步（编辑）1年前
我建议谨慎使用“……恢复健康”和“……她取得了显著的康复”这两个短语。静脉注射免疫球蛋白（IVIg）并非SPS的治愈方法，如果给人造成它能治愈SPS的印象，那就太草率了。IVIg对她和其他SPS患者的作用是减轻症状、延缓病情进展并增强活动能力，而不是治愈。我理解帖子的用意，但作为一名SPS患者的照护者，我陪妻子接受IVIg输注近60次，我可以肯定地说，IVIg无疑是对抗SPS、提高生活质量的有效手段，但绝非万能药。
Kevin Welsh • 3rd+
David Fajgenbaum，医学博士、工商管理硕士、理学硕士：我最近加入了一家在医疗保健领域人工智能方面做出卓越贡献的公司。我非常希望能与您和您的团队交流，并分享更多信息。特别是关于我们如何创建患者的数字孪生模型——模拟每位患者独特的生理、神经和免疫特征的虚拟模型。这些数字孪生模型可以让您的团队在将治疗方案应用于患者之前，在虚拟环境中测试各种治疗方案。请联系 kevin@dv8.bz 或直接发送消息。谢谢！
Lauren McDermott • 3rd+
感谢您分享这些信息。静脉注射免疫球蛋白 (IVIg) 让我得以从僵人综合征 (SPS) 的折磨中恢复过来。虽然它不如以前那么有效，但仍然有助于减轻痉挛和疼痛。
Lauren McDermott
非常感谢您分享您的经历。我很高兴听到它对您有所帮助。希望它现在也能像以前一样有效。期待未来的治疗方法。
Tara Zier • 3rd+
正如 Lauren McDermott 所提到的，许多 SPS 患者都有类似的经历，即 IVIG 有助于减轻症状，但随着时间的推移，其疗效会逐渐减弱。我还想强调的是，即使 SPS 患者在短时间内能够保持高水平的竞技状态，也不意味着他们的病情已经好转。事件发生前后的“前后”都可能非常残酷。我对此深有体会。我们需要更好的SPS治疗方法，也许它正被束之高阁。正因如此，我非常感激您所做的一切，David Fajgenbaum，医学博士、工商管理硕士、理学硕士。谢谢您！！
Daniel Adongo博士 • 第三任及以上
主席
恭喜您！来自www.apostledanieladongo.org，他同时也是一位著作颇丰的作家，以及一位ICF认证的生活教练。我曾在我的著作《振动法则——西利塔·姆贝雷雷疗愈之水（系列三）》中提到过您从危及生命的疾病中幸存下来的鼓舞人心的故事。
Celine Dion got her voice back thanks in part to a repurposed drug
https://www.linkedin.com/posts/davidfajgenbaum_drugrepurposing-everycure-stiffpersonsyndrome-activity-7241876072336691202-SFon/
By David Fajgenbaum, MD, MBA, MSc
Physician-Scientist @ UPenn | Co-Founder & President @ Every Cure | Bestselling Author, Chasing My Cure
2025 TEDPhysician-Scientist 2025 TED
About David Fajgenbaum
MD, MBA, MSc, is co-Founder & President of Every Cure and a physician-scientist at the University of Pennsylvania, where he is one of the youngest faculty members ever to receive tenure at Penn Medicine. He is also the national bestselling author of Chasing My Cure: A Doctor’s Race to Turn Hope Into Action, which is being adapted into a film by Forrest Gump producer Wendy Finerman.
Celine Dion got her voice back thanks in part to a repurposed drug!
Diagnosed with stiff person syndrome, a rare disease that took away her ability to walk, talk, and sing, she has fought an inspiring battle.
Through intense physical therapy and the use of IVIg, a repurposed drug originally developed in 1952, she was able to regain some of her health.
This powerful example of using IVIg for stiff person syndrome is exactly why Every Cure exists—to uncover more uses like this and ensure that every patient can benefit from existing medicines.
Human Progress(edited) 1y
I would caution using the phrases, "...regain her health." AND "...she was able to make a remarkable recovery." IVIg is not a cure for SPS and would be reckless to give the impression it provided her with a cure. What IVIg enabled for her, and others suffering from SPS, is a lessening of symptoms and the potential slowing of progression and the strength to perform, not a cure. I appreciate the sentiment of the post but as a care giver of someone with SPS, who's taken his wife to IVIg infusions almost 60 times, IVIg is certainly a wonderful tool, in the arsenal to fight SPS and improve quality of life, but by no means a panacea.
Kevin Welsh • 3rd+
David Fajgenbaum, MD, MBA, MSc I've recently joined a company that is doing remarkable things in Artificial General Intelligence in healthcare. I'd love to connect and show you and your team more. Particularly around how we can create a digital twin of patients—virtual models that simulate each patient's unique physiological, neurological, and immunological characteristics. These digital twins would allow your team to test various treatment scenarios in a virtual environment before applying them to the patient. Reach out to kevin@dv8.bz or connect in direct message. Thank you!
Lauren McDermott • 3rd+
Thank you for sharing this information. IVIg has kept me alive with Stiff Person Syndrome. It’s not as effective as it used to be, but it still helps with reducing spasms and pain.
Lauren McDermott
thanks so much for sharing about your experience. I’m so glad to hear that it’s helped you. Wish it was as effective now as it was before. Hopeful for future treatments.
Tara Zier • 3rd+
As Lauren McDermott mentioned, many SPS patients have a similar experience where IVIG helps reduce symptoms but loses effectiveness over time. I also want to emphasize just because someone with SPS can perform at a high level for a brief period of time doesn’t mean they are better. The “before” and “after” the event can be brutal. I can speak to this from personal experience. We need a better treatment for SPS and maybe it is sitting on a shelf. That’s why I’m grateful for all of the work you are doing David Fajgenbaum, MD, MBA, MSc. Thank you!!
Dr. Daniel Adongo • 3rd+
President
Congratulations from here at: www.apostledanieladongo.org who is ALSO an AUTHOR of many books and an ICF Certified Life Coach. I actually mention your INSPIRING story of survival from a life-threatening disease in one of my books Entitled: "The Law of Vibration - On The Healing Waters of Silita Mberere (Series III).
https://www.linkedin.com/posts/davidfajgenbaum_drugrepurposing-everycure-stiffpersonsyndrome-activity-7241876072336691202-SFon/
作者：大卫·法根鲍姆，医学博士、工商管理硕士、理学硕士
宾夕法尼亚大学医师科学家 | Every Cure 联合创始人兼总裁 | 畅销书《追寻我的治愈之路》作者
2025 TED 医师科学家
关于大卫·法根鲍姆
医学博士、工商管理硕士、理学硕士，是 Every Cure 的联合创始人兼总裁，也是宾夕法尼亚大学的医师科学家。他是宾夕法尼亚大学医学院有史以来最年轻的终身教职人员之一。他也是畅销书《追寻我的治愈：一位医生将希望化为行动的竞赛》（Chasing My Cure: A Doctor’s Race to Turn Hope Into Action）的作者，该书已被《阿甘正传》制片人温迪·芬纳曼改编成电影。
席琳·迪翁重获歌喉，部分要归功于一种重新利用的药物！
她被诊断出患有僵人综合征，这是一种罕见疾病，使她失去了行走、说话和唱歌的能力。她与病魔进行了一场鼓舞人心的斗争。
通过高强度的物理治疗和使用静脉注射免疫球蛋白（IVIg，一种最初于1952年开发的药物），她得以恢复部分健康。
这个使用IVIg治疗僵人综合征的有力案例，正是“万能疗法”（Every Cure）存在的意义所在——发掘更多类似的用途，确保每位患者都能从现有药物中受益。
人类进步（编辑）1年前
我建议谨慎使用“……恢复健康”和“……她取得了显著的康复”这两个短语。静脉注射免疫球蛋白（IVIg）并非SPS的治愈方法，如果给人造成它能治愈SPS的印象，那就太草率了。IVIg对她和其他SPS患者的作用是减轻症状、延缓病情进展并增强活动能力，而不是治愈。我理解帖子的用意，但作为一名SPS患者的照护者，我陪妻子接受IVIg输注近60次，我可以肯定地说，IVIg无疑是对抗SPS、提高生活质量的有效手段，但绝非万能药。
Kevin Welsh • 3rd+
David Fajgenbaum，医学博士、工商管理硕士、理学硕士：我最近加入了一家在医疗保健领域人工智能方面做出卓越贡献的公司。我非常希望能与您和您的团队交流，并分享更多信息。特别是关于我们如何创建患者的数字孪生模型——模拟每位患者独特的生理、神经和免疫特征的虚拟模型。这些数字孪生模型可以让您的团队在将治疗方案应用于患者之前，在虚拟环境中测试各种治疗方案。请联系 kevin@dv8.bz 或直接发送消息。谢谢！
Lauren McDermott • 3rd+
感谢您分享这些信息。静脉注射免疫球蛋白 (IVIg) 让我得以从僵人综合征 (SPS) 的折磨中恢复过来。虽然它不如以前那么有效，但仍然有助于减轻痉挛和疼痛。
Lauren McDermott
非常感谢您分享您的经历。我很高兴听到它对您有所帮助。希望它现在也能像以前一样有效。期待未来的治疗方法。
Tara Zier • 3rd+
正如 Lauren McDermott 所提到的，许多 SPS 患者都有类似的经历，即 IVIG 有助于减轻症状，但随着时间的推移，其疗效会逐渐减弱。我还想强调的是，即使 SPS 患者在短时间内能够保持高水平的竞技状态，也不意味着他们的病情已经好转。事件发生前后的“前后”都可能非常残酷。我对此深有体会。我们需要更好的SPS治疗方法，也许它正被束之高阁。正因如此，我非常感激您所做的一切，David Fajgenbaum，医学博士、工商管理硕士、理学硕士。谢谢您！！
Daniel Adongo博士 • 第三任及以上
主席
恭喜您！来自www.apostledanieladongo.org，他同时也是一位著作颇丰的作家，以及一位ICF认证的生活教练。我曾在我的著作《振动法则——西利塔·姆贝雷雷疗愈之水（系列三）》中提到过您从危及生命的疾病中幸存下来的鼓舞人心的故事。
Celine Dion got her voice back thanks in part to a repurposed drug
https://www.linkedin.com/posts/davidfajgenbaum_drugrepurposing-everycure-stiffpersonsyndrome-activity-7241876072336691202-SFon/
By David Fajgenbaum, MD, MBA, MSc
Physician-Scientist @ UPenn | Co-Founder & President @ Every Cure | Bestselling Author, Chasing My Cure
2025 TEDPhysician-Scientist 2025 TED
About David Fajgenbaum
MD, MBA, MSc, is co-Founder & President of Every Cure and a physician-scientist at the University of Pennsylvania, where he is one of the youngest faculty members ever to receive tenure at Penn Medicine. He is also the national bestselling author of Chasing My Cure: A Doctor’s Race to Turn Hope Into Action, which is being adapted into a film by Forrest Gump producer Wendy Finerman.
Celine Dion got her voice back thanks in part to a repurposed drug!
Diagnosed with stiff person syndrome, a rare disease that took away her ability to walk, talk, and sing, she has fought an inspiring battle.
Through intense physical therapy and the use of IVIg, a repurposed drug originally developed in 1952, she was able to regain some of her health.
This powerful example of using IVIg for stiff person syndrome is exactly why Every Cure exists—to uncover more uses like this and ensure that every patient can benefit from existing medicines.
Human Progress(edited) 1y
I would caution using the phrases, "...regain her health." AND "...she was able to make a remarkable recovery." IVIg is not a cure for SPS and would be reckless to give the impression it provided her with a cure. What IVIg enabled for her, and others suffering from SPS, is a lessening of symptoms and the potential slowing of progression and the strength to perform, not a cure. I appreciate the sentiment of the post but as a care giver of someone with SPS, who's taken his wife to IVIg infusions almost 60 times, IVIg is certainly a wonderful tool, in the arsenal to fight SPS and improve quality of life, but by no means a panacea.
Kevin Welsh • 3rd+
David Fajgenbaum, MD, MBA, MSc I've recently joined a company that is doing remarkable things in Artificial General Intelligence in healthcare. I'd love to connect and show you and your team more. Particularly around how we can create a digital twin of patients—virtual models that simulate each patient's unique physiological, neurological, and immunological characteristics. These digital twins would allow your team to test various treatment scenarios in a virtual environment before applying them to the patient. Reach out to kevin@dv8.bz or connect in direct message. Thank you!
Lauren McDermott • 3rd+
Thank you for sharing this information. IVIg has kept me alive with Stiff Person Syndrome. It’s not as effective as it used to be, but it still helps with reducing spasms and pain.
Lauren McDermott
thanks so much for sharing about your experience. I’m so glad to hear that it’s helped you. Wish it was as effective now as it was before. Hopeful for future treatments.
Tara Zier • 3rd+
As Lauren McDermott mentioned, many SPS patients have a similar experience where IVIG helps reduce symptoms but loses effectiveness over time. I also want to emphasize just because someone with SPS can perform at a high level for a brief period of time doesn’t mean they are better. The “before” and “after” the event can be brutal. I can speak to this from personal experience. We need a better treatment for SPS and maybe it is sitting on a shelf. That’s why I’m grateful for all of the work you are doing David Fajgenbaum, MD, MBA, MSc. Thank you!!
Dr. Daniel Adongo • 3rd+
President
Congratulations from here at: www.apostledanieladongo.org who is ALSO an AUTHOR of many books and an ICF Certified Life Coach. I actually mention your INSPIRING story of survival from a life-threatening disease in one of my books Entitled: "The Law of Vibration - On The Healing Waters of Silita Mberere (Series III).