多年来，饮食健康总是一个没有定论的话题，各路专家们（注意，Ta们都是正规的，在高影响因子的杂志发表论文的专家）各说不一。什么 Plant based diet, Ketogenic diet........把我们这些外行人弄的昏头转向。
一直认为，低碳饮食是抗癌的方向。有很多论文了。大家自己去看吧。但最近，中国的研究者们又发现了相反的实验数据：低碳饮食可能会促进癌症的肺转移！妈呀！这一下大家更昏头转向了。
这是一篇基础医学论文，发表在今年的Cell 杂志上（很高影响因子的杂志）。我只是一个医者，大概明白论文的意思（勉强用Google translate 译成中文，并修饰了一下）。用心的读者可以直接读原文（如下）。
大概意思是，低碳（剥夺葡萄糖）饮食会通过一系列反应（亚细胞结构，酶，细胞信号），影响到巨噬细胞，最后导致自然杀伤细胞（NK）的耗竭（NK 细胞是抗肿瘤细胞）， 从而建立了肿瘤转移的微环境。
文章最后说：低碳抗癌的探究/方向，既提供了抗肿瘤治疗的思路，也提供了肿瘤转移危险的思路（双刃剑）！ 朋友们，自己选择吧！
摘要的中文翻译
葡萄糖代谢作为靶向
英文摘要
Targeting glucose metabolism has emerged as a promising strategy for inhibiting tumor growth. However, we herein uncover an unexpected paradox: while glucose deprivation through a low-carbohydrate diet or impaired in situ metabolism suppresses primary tumor growth, it simultaneously promotes lung metastasis by depleting natural killer (NK) cells via lung macrophages. Mechanistically, glucose deprivation induces endoplasmic reticulum (ER) stress, activating HMG-CoA reductase degradation protein 1 (HRD1) to catalyze K63-linked ubiquitination of TRAIL, which is then packaged into exosomes via the endosomal sorting complex required for transport (ESCRT) complex. These exosomal TRAIL molecules polarize PVR+ macrophages, triggering NK cell exhaustion and establishing a pre-metastatic niche. Notably, TIGIT blockade not only prevents metastasis induced by glucose deprivation but also enhances its anti-tumor effects. Clinically, low glucose metabolism correlates with higher 2-year postoperative recurrence across 15 cancer types. Furthermore, plasma exosomal TRAIL outperforms traditional markers, such as α-fetoprotein (AFP) and tumor size, in predicting early postoperative lung metastasis, revealing both the risks and therapeutic potential of targeting glucose metabolism.
下面是本文的发表的杂志（Cell）题目，和作者
